Stability of lyophilized siRNA nanosome formulations

Effect of Helper Lipids on Stability and Transfection Activity of Lyophilized Lipoplex Formulations of Antisense and DOTAP Nanoliposomes

       Survivin, an inhibitor of apoptosis protein is highly expressed in most cancers and considered as an attractive target for cancer antisense therapy. To vectorize antisense molecules, cationic nanoliposomes are generally used; however, their complexes are too instable, during shelf-life and upon exposure to blood components and extracellular matrix, to be used in-vivo. The present study a...

The influence of water on the stability of lyophilized formulations with inositol and mannitol as excipients.

The stability of a moisture-sensitive drug in lyophilized products was investigated under conditions with varying water content and temperature using two model formulations: a formulation containing inositol (IF) as the excipient and a formulation containing mannitol (MF) as the excipient. IF showed better chemical stability (a lower hydrolysis rate) than MF when both formulations contained 2% ...

Methods of Measuring the Tg of Lyophilized Protein-Excipient Formulations

mixtures strives to develop a product with good shelf life and that allows efficient dissolution by the end user with minimal change to the properties of the drug. One of the key properties used in the design of the formulations is the glass transition temperature, Tg, which must be sufficiently above the storage temperature to limit any degradation properties from occurring at significant rate...

Rational design of stable lyophilized protein formulations: theory and practice.

Heat stability of the lyophilized Sabin poliovaccine.

In this study we lyophilized three types of live attenuated polioviruses (Sabin vaccine strains) and evaluated the lyophilized vaccine viruses' heat stability. The virus titers were measured after heating at 37 and 45 and then compared with the titers of conventional liquid vaccine viruses similarly treated. The results showed that lyophilization, while slightly reducing vaccine virus titers,...